Habituation occurs due to changes in the transmission of nerve impulses at the synapse between two neurones.
With repeated stimulation, the calcium ion channels in the presynaptic membrane become less responsive, leading to a decreased influx of ions when an action potential arrives.
Because fewer ions enter the presynaptic knob, fewer vesicles containing neurotransmitters fuse with the presynaptic membrane and release their contents into the synaptic cleft.
Consequently, fewer neurotransmitter molecules bind to receptors on the postsynaptic membrane, resulting in fewer sodium ion () channels opening.
Due to the reduced opening of channels, the postsynaptic membrane does not undergo sufficient depolarisation to reach the threshold potential.
If the threshold potential is not reached, no action potential is generated in the postsynaptic neurone.
The signal fails to reach the effector organ (such as a muscle), and the animal exhibits no behavioral response to the stimulus.
Sequence is Key: When describing the mechanism, always follow the flow: influx Vesicle fusion Neurotransmitter release channel opening Threshold potential.
Specify the Ions: Do not just say 'ions'. Be explicit about Calcium () at the presynaptic membrane and Sodium () at the postsynaptic membrane.
Conditionality: Remember that habituation only occurs if there is no negative or positive outcome. If the stimulus is paired with a shock or food, the animal will not habituate; it will undergo associative learning instead.
Check for Reversal: If an exam question mentions the stimulus suddenly becoming louder or faster, the answer should involve the 'resetting' of the response.